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Weight Loss Patent Abstract
Compositions and methods for administering a diet supplement to
humans are provided for the enhancement of weight loss, suppression
of appetite, prevention of muscle protein catabolism, and providing
antioxidants in either a daytime or nighttime formulation. Said
diet supplement is comprised of at least a source of Catechins and
at least 3% Corosolic Acid. The diet supplement is provided in either
daytime or nighttime formulations.
Weight Loss Patent Claims
1. A diet supplement for promoting weight loss comprising at least
3% Corosolic acid and a source of Catechins.
2. The diet supplement of the claim 1 further, comprising Chamomile
Extract.
3. The diet supplement of claim 1 further, comprising Green Tea
Extract.
4. The diet supplement of claim 2, further comprising Caffeine-free
White Tea Extract.
5. The diet supplement of claim 4, further comprising Caffeine-free
Oolong Tea Extract.
6. The diet supplement of claim 3, further comprising White Tea
Extract.
7. The diet supplement of claim 6, further comprising Oolong Tea
Extract.
8. The diet supplement of claim 5, further comprising Passionflower
Extract.
9. The diet supplement of claim 8, further comprising Caffeine-free
Green Tea Extract.
10. The diet supplement of claim 9, further comprising a blend
of N-olyl-phosphatidyl ethanolamine and Epigal locatechin-3-gallate.
11. The diet supplement of claim 7, further comprising Rooibos
Tea Powder.
12. The diet supplement of claim 11, further comprising Vinpocetine.
13. The diet supplement of claim 12, further comprising Coleus
Forskholli.
14. The diet supplement of claim 13, further comprising Theobroma
Cacao Extract.
15. The diet supplement of claim 14, further comprising Evodia
Rutaecarpa Fruit Extract.
16. The diet supplement of claim 15, further comprising Black Tea
Extract.
17. A method for enhancing weight loss comprising the step of administrating
a diet supplement that comprises at least 3% Corosolic acid and
a source of Catechins.
18. A method for improving lean body mass comprising the step of
administrating a diet supplement that comprises at least 3% Corosolic
Acid and a source of Catechins.
19. A method for inducing relaxation comprising the step of administrating
a diet supplement that comprises at least 3% Corosolic acid and
Apigenin.
20. A method of appetite suppression comprising the step of administrating
a diet supplement that comprises at least 3% Corosolic acid and
a source Catechins.
21. The diet supplement of claim 16 to be taken immediately upon
waking in the morning.
22. The diet supplement of claim 16 comprising a rapid-release
oral mode of delivery.
23. The diet supplement of 7 comprising a soft-gelatin caplet oral
mode of delivery.
24. The diet supplement of claim 9 comprising a soft-gelatin caplet
oral mode of delivery.
25. The diet supplement of claim 22, comprising in daytime formulation.
26. The diet supplement of claims 23 and 24 comprising a nighttime
formulation.
Weight Loss Patent Description
RELATED APPLICATIONS
[0001] The application is related to and claims benefit of priority
to Applicant's co-pending U.S. Provisional Patent Application Ser.
No. 60/735,040 entitled "Compositions and Methods for Weight-loss
and Weight-loss Maintenance," filed Nov. 22, 2005, the disclosure
of which is hereby fully incorporated by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to a nutritional composition
for enhancing weight loss via GLUT4 stimulation and subsequent glycogenolysis.
Moreover, the present invention may serve to enhance weight loss
by suppressing appetite, preventing muscle protein catabolism, providing
antioxidants and/or inducing relaxation in a formulation that may
be taken, e.g., immediately prior to sleep. A second embodiment
may be taken upon waking from sleep, e.g., in the morning.
SUMMARY OF THE INVENTION
[0003] The present invention provides for a composition for enhancing
weight loss, suppressing appetite, preventing muscle protein catabolism,
providing antioxidants and/or inducing relaxation. The composition
of the present invention comprises at least a source of Catechins
and at least 3% Corosolic Acid. The present invention may provide
a composition and method that reduces fat body mass, and increases
weight loss, leading to a desired body composition, while inducing
relaxation and providing antioxidants in a stimulant-free formula.
For example, the composition and method may allow a person's body
to oxidize more stored body fat than they would otherwise burn,
which in turn reduces body fat mass and leads to a change in body
composition, ultimately leading to fat loss.
[0004] Additionally, the present invention may provide for a composition
for enhancing weight loss, suppressing appetite, and preventing
muscle protein catabolism. According to an embodiment of the invention,
there is provided a composition and method that reduces fat body
mass, and increases weight loss, leading to a desired body composition
in a rapid-release technology that may be taken upon waking in the
morning. For example, the composition and method may allow a person's
body to oxidize more stored body fat then they would otherwise burn,
which in turn reduced body fat mass and leads to changes in body
composition, ultimately leading to fat loss.
DETAILED DESCRIPTION OF THE INVENTION
[0005] The present invention, according to an embodiment thereof,
is directed towards a nutritional composition for enhancing weight
loss, suppressing appetite, preventing muscle protein catabolism,
providing antioxidants and/or inducing relaxation. The composition
may be a diet supplement. According to an embodiment of the present
invention, there is provided a composition that reduces fat body
mass and increases weight loss. For example, the composition and
method may allow a person's body to oxidize more stored body fat
than they would otherwise burn, which in turn reduces body fat,
ultimately leading to fat loss.
[0006] Furthermore, in addition or alternatively, according to
an embodiment of the present invention, there is provided a composition
that improves or induces relaxation. For example, the present embodiment,
taken as a nighttime supplement, may induce relaxation, while suppressing
appetite and inducing weight loss via a non-thermogenic, glyogenolytic
process.
[0007] The present invention, according to a second embodiment
thereof, is directed towards a diet supplement for enhancing weight
loss, suppressing appetite, and/or preventing muscle protein catabolism.
According to the second embodiment of the present invention, there
is provided a composition that reduces fat body mass and increases
weight loss that may be taken in the morning upon waking from sleep.
For example, the composition and method may allow a person's body
to oxidize more stored body fat then they would otherwise burn,
which in turn reduces total body fat, ultimately leading to fat
loss.
[0008] In a first embodiment, the present invention may include
the use of a combination, wherein the combination includes one or
more of, without being limited to, Banaba Leaf Extract (containing
1%, 3%, or higher concentrations of Corosolic Acid), Caffeine-free
Green Tea Leaf Extract, N-olyl-phosphatidyl ethanolamine, Caffeine-free
White Tea Dry Leaf Extract, Caffeine-free Oolong Tea Dry Leaf Extract,
Chamomile, and Passionflower. The supplement dosage may be consumed
in any form, e.g., a capsule, a tablet, a caplet or as a dietary
gel. In an embodiment, the dosage is provided in a soft gelatin
capsule.
[0009] In the second embodiment, the present invention may include
the use of a combination, wherein the combination includes one or
more of, without being limited to, Green Tea Leaf Extract, Anhydrous
Caffeine, Banaba Leaf Extract (containing 1%, 3%, or higher concentrations
of Corosolic Acid), Black Tea Leaf Extract, White Tea Leaf Extract,
Oolong Tea Leaf Extract, Rooibos Tea Powder, Vinpocetine, Coleus
Forskholli Extract, Theobroma Cacao Extract, and Evodia Rutaecarpa
Fruit Extract. The dosage may be consumed in any form, e.g., a capsule,
a tablet, or as dietary gel. In an embodiment, the dosage is provided
in a rapid-release capsule.
[0010] In the third embodiment, the present invention may include
the use of a combination, wherein the combination includes one or
more of, without being limited to, Banaba Leaf Extract (containing
1%, 3%, or higher concentrations of Corosolic Acid), Green Tea Leaf
Extract, White Tea Leaf Extract, and Oolong Tea Leaf Extract. The
dosage may be consumed in any form, e.g., a capsule, a tablet, or
as dietary gel. In an embodiment, the dosage is provided in a soft-gelatin
capsule.
[0011] Furthermore, the dosage form of the diet supplement in accordance
with these embodiments may be provided in accordance with customary
processing techniques for herbal and/or dietary supplements in any
of the forms mentioned above.
[0012] In an embodiment of the present invention, a diet supplement
may include Banaba Leaf Extract (containing 1%, 3%, or higher concentrations
of Corosolic Acid), Caffeine-free Green Tea Leaf Extract, N-olyl-phosphatidyl
ethanolamine, Caffeine-free White Tea Dry Leaf Extract, Caffeine-free
Oolong Tea Dry Leaf Extract, Chamomile, Passionflower, Soybean oil,
gelatin, glycerin, Yellow Beeswax, Purified Water, Lecithin, Titanium
Dioxide, FD&C Blue #1, maltodextrin, shellac glaze, n-butyl
alcohol, isopropyl alcohol, propylene glycol, and ammonium hydroxide,
such as set forth in greater detail in Example 1. This diet supplement
may be provided for increasing a person's natural adipose lipolytic
metabolism via a non-thermogenic, glycogenolytic process.
[0013] In a second embodiment, the present invention may include
Green Tea Leaf Extract, Anhydrous Caffeine, Banaba Leaf Extract
(containing 1%, 3%, or higher concentrations of Corosolic Acid),
Black Tea Leaf Extract, White Tea Leaf Extract, Oolong Tea Leaf
Extract, Rooibos Tea Powder, Vinpocetine, Coleus Forskholli Extract,
Theobroma Cacao Extract, and Evodia Rutaecarpa Fruit Extract, Microcrystalline
Cellulose, Croscarmellose Sodium, Vegetable Stearine, Magnesium
Strearate, Silica, Hydroxypropylcellulose, Polyvinyl Alcohol, Polysorbate
Glycol, FD&C Red #40 Aluminum Lake, Talc, Titanium Dioxide,
Polysorbate 80, Shellac Glaze, Isopropyl Alcohol, Propylene Glycol,
Ammonium Hydroxide, Acesulfame Potassium, Maltodextrin, Sodium Glucolate,
and Sodium Chloride, such as set forth in greater detail in Example
2. This diet supplement may be provided for increasing a person's
natural adipose lipolytic metabolism, leading to fat loss in an
accelerated weight loss formula.
[0014] In a third embodiment, the present invention may include
Banaba Leaf Extract (containing 1%, 3%, or higher concentrations
of Corosolic Acid), Green Tea Leaf Extract, White Tea Leaf Extract,
Oolong Tea Leaf Extract, Safflower Oil, Fish Gelatin, Glycerin,
Yellow Beeswax, Purified Water, Titanium Dioxide, and Cochineal
Extract, such as set forth in greater detail in Example 3. This
diet supplement may be provided for increasing a person's natural
adipose lipolytic metabolism, leading to fat loss in an accelerated
weight loss formula.
[0015] The present invention, in various stimulant-free embodiments,
may be employed in a nighttime formulation for increasing a person's
natural adipose metabolism via a non-thermogenic, glycogenolytic,
thus leading to a desired body fat composition. Other embodiments
of the present invention, that may be administered in a daytime
formulation, may be employed for increasing a person's natural adipose
metabolism, leading to accelerated weight loss. The compositions
of the present invention may be of particular interest to those
seeking to lose fat body mass and increase weight loss. The amount
of the composition administered to the person may vary depending
upon, e.g., the desired effect, body mass, the individual characteristics
of the person, and other such factors. For example, in various embodiments,
the compositions of the present invention may be administered to
the diet of the person on a daily basis in nighttime formulation
immediately prior to a person going to sleep, or alternatively,
in a daytime formulation administered in the morning immediately
after waking from sleep.
[0016] In the present invention, the insulin-responsive Glute 4
Glucose transport receptor (GLUT4) is stimulated. Studies have shown
that Banaba Leaf Extract components are able to stimulate GLUT4
translocation and adipocyte differentiation inhibition in certain
cells types (Liu, X., Kim, J. K., Li, Y., Li, J., Liu, F., Chen,
X., "Tannic acid stimulates glucose transport and inhibits
adipocyte differentiation in 3T3-L1 cells", J. Nutr. 2005 February;
135(2):165-71). Moreover, components of Banaba Leaf Extract have
also been shown to be able to reduce blood glucose via GLUT4 stimulation
and translocation (Miura, T., Itoh. Y., Kaneko, T., Ueda, N., Ishida,
T., Fukushima, M., Matsuyama, F., Seino, Y., "Corosolic acid
induces GLUT4 translocation in genetically type 2 diabetic mice,"
Biol. Pharm. Bull., 2004 July; 27(7):1103-5). Therefore, it follows
that an increase in GLUT4 receptor population is accompanied by
an increase in glucose being transported from the blood into brown
and white adipocytes as well as skeletal muscle (Groff, J. L., Gropper,
S. S., "Advanced Nutrition and Human Metabolism," 3.sup.rd
Edition. Wadsworth Thomson Learning, Scarborough, Ontario. 1999).
The increased amount of glucose being transported from the blood
into cells leads to a decrease in blood-glucose levels which stimulates
the release of pancreatic glucagon (Groff, J. L., Gropper, S. S.,
"Advanced Nutrition and Human Metabolism," 3.sup.rd Edition,
Wadsworth Thomson Learning, Scarborough, Ontario. 1999). Glucagon
then stimulates the release of fatty acids into the blood via lipolysis
which are converted into glucose in the liver to restore the blood-glucose
to its homeostatic level. Therefore, when the fat cells are catabolized
to produce glucose, a loss in weight is observed. The present embodiments
of the composition may reduce body fat mass and lead to a change
in body composition via this mechanism, in part or in whole, or
in combination with other mentioned mechanisms.
[0017] Moreover, in a randomized double blind clinical trial, no
great increase in resting metabolic rate or in oxygen consumption
was observed. This suggests that the present invention acts via
a non-thermogenic mechanism. Further evidence to this end is supported
by the fact that no symptoms of feeling hot, diaphoresis, or an
increased temperature were reported (Judy, W. V., "A randomized
double blind placebo controlled clinical trial evaluating the effects
of Glucotrim.RTM. containing 3% corosolic acid on weight loss, lean
and fat body mass, metabolic rate and blood sugar," SGTI protocol
WLGT 0.03-2003. 2003) during a clinical trial employing an active
ingredient of the composition.
[0018] U.S. Pat. No. 6,784,206 discloses a method of manufacture
of a soft-gel capsule comprising 1% Corosolic acid, wherein the
Corosolic acid is absorbed into the intestinal tract of a human
in order to sustain weight loss management and maintain blood sugar
levels. Moreover, this patent purports to aim to improve high blood
sugar levels in subjects suffering from non-insulin dependant diabetes
mellitus.
[0019] The present invention, according to various embodiments,
may also protect against oxidative stress through the use of antioxidants.
Catechins have been shown to exhibit properties of antioxidants
and thus protect against free radical damage (Ueda, J., Saito, N.,
Shimazu, Y., Ozawa, T., "A comparison of scavenging abilities
of antioxidants against hydroxyl radicals," Arch. Biochem.
Biophys., 1996, Sep. 15; 333(2):377-84). Fatty acids are transported
into the mitochondria via a covalent linkage to L-carnitine (Groff,
J. L., Gropper, S. S., "Advanced Nutrition and Human Metabolism,"
3.sup.rd Edition, Wadsworth Thomson Learning, Scarborough, Ontario,
1999). The oxidation of fatty acids is localized within tissues
to the mitochondria, which are susceptible to oxidative stress and
membrane damage. Free radicals can be formed as part of the electron
transport chain which can lead to oxidative stress on the mitochondrial
membrane (Groff, J. L., Gropper, S. S., "Advanced Nutrition
and Human Metabolism," 3.sup.rd Edition, Wadsworth Thomson
Learning, Scarborough, Ontario, 1999) leading to cellular death.
Catechins scavenge reactive oxygen species and act as antioxidants,
thus protecting against free radical damage (Ueda, J., Saito, N.,
Shimazu, Y., Ozawa, T., "A comparison of scavenging abilities
of antioxidants against hydroxyl radicals," Arch. Biochem.
Biophys., 1996 Sep. 15; 333(2):377-84). The compositions of the
present invention, according to various embodiments thereof, may
afford protection against organelle oxidative stress via this mechanism,
in part or in whole, or in combination with other mentioned mechanisms.
[0020] Moreover, epigallocatechin-3-gallate (EGCG), but not related
catechins, have been experimentally shown to significantly reduced
food intake and thus lead to a reduced body weight (Kao, Y. H.,
Hiipakka, R. A., Liao, S. "Modulation of endocrine systems
and food intake by green tea epigallocatechin gallate." Endocrinology,
2000 March; 141(3):980-7). Further to this, Catechins have also
been shown to suppress intracellular lipid accumulation. The same
study also suggests that catechins increase weight loss through
the suppression of adipocyte differentiation (Furuyashiki, T., Nagayasu,
H., Aoki, Y., Bessho, H., Hashimoto, T., Kanazawa, K., Ashida, H.,
"Tea catechin suppresses adipocyte differentiation accompanied
by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells."
Biosci. Biotechnol. Biochem. 2004 November; 68(11):2353-9). The
compositions of the present invention, according to various embodiments,
may reduce body fat mass and to a change in body composition via
this mechanism, in part or in whole, or in combination with other
mentioned mechanisms.
[0021] The present invention, according to an embodiment thereof,
may additionally acts as an appetite suppressant. Peroxisome-proliferator-activated
receptors-.alpha. (PPAR-.alpha.) are found in the intestinal tract.
When activated, these receptors are responsible for signaling to
the hypothalamus to decrease appetite leading to a reduction in
body weight (Fu, J., Gaetani, S., Oveisi, F., Lo Verme, J., Serrano,
A., Rodriguez De Fonseca, F., Rosengarth, A., Luecke, H., Di Giacomo,
B., Tarzia, G., Piomelli, D., "Oleylethanolamide regulates
feeding and body weight through activation of the nuclear receptor
PPAR-alpha." Nature, 2003, Sep. 4; 425(6953):90-3). The compositions
of the present invention, according to various embodiments, may
reduce body fat mass and lead to a change in body composition via
this mechanism, in part or in whole, or in combination with other
mentioned mechanisms.
[0022] Furthermore, the present invention, according to various
embodiments thereof, may also include compositions which initiate
the transcription of proteins involved in lipid metabolism as well
as repressing inducible nitric oxide synthase, an enzyme that may
contribute to feeding stimulation (Fu, J., Gaetani, S., Oveisi,
F., Lo Verme, J., Serrano, A., Rodriguez De Fonseca, F., Rosengarth,
A., Luecke, H., Di Giacomo, B., Tarzia, G., Piomelli, D., "Oleylethanolamide
regulates feeding and body weight through activation of the nuclear
receptor PPAR-alpha," Nature, 2003 Sep. 4; 425(6953):90-3).
The compositions of the present invention, according to various
embodiments, may reduce body fat mass and lead to a change in body
composition via this mechanism, in part or in whole, or in combination
with other mentioned mechanisms.
[0023] Moreover, the present invention, according to various embodiments
thereof, may also include compositions which may be effective in
inducing relaxation and possessing anxiolytic properties via binding
to the benzodiazepine binding site in the gamma-aminobutyric acid
receptor type A (GABA(A)) (Fernandez, S. P., Wasowski, C., Paladini,
A. C., Marder, M., "Synergistic interaction between hesperidin,
a natural flavonoid, and diazepam," Eur. J. Pharmacol., 2005
Apr. 11; 512(2-3):189-98). The action of this ligand leads to sedation
and a reduction in locomotor activity (Avallone, R., Zanoli, P.,
Puia, G., Kleinschnitz, M., Schreier, P., Baraldi, M., "Pharmacological
profile of apigenin, a flavonoid isolated from Matricaria chamomilla,"
Biochem. Pharmacol., 2000 Jun. 1; 59(11):1387-94) without impairing
memory or motor skills (Salgueiro, J. B., Ardenghi, P., Dias, M.,
et al., "Anxiolytic natural and synthetic flavonoid ligands
of the central benzodiazepine receptor have no effect on memory
tasks in rats." Pharmacol. Biochem. Behav., 1997; 58(4):887-91).
The compositions of the present invention, according to various
embodiments, may act as a sedative leading to the induction of relaxation.
The compositions of the present invention, according to various
embodiments, may reduce body fat mass by inducing sleep so as to
prevent food intake and thus to prevent increased levels of glucose
being stored as fat or functional stress which again may increase
blood-glucose levels.
[0024] The present invention, according to various embodiments
thereof, provides a method which includes consuming a composition,
wherein the method enhances weight loss, suppressing appetite, preventing
muscle protein catabolism, providing antioxidants and/or inducing
relaxation. According to another embodiment, there is provided a
method which includes consuming a composition, wherein the method
enhances weight loss, suppresses appetite, and/or prevents muscle
protein catabolism. The method of the present invention may include
the step of consuming a composition in the form of a nighttime diet
supplement, whereas the method of another embodiment of the present
invention may include the step of consuming a composition in the
form of a daytime diet supplement. According to various embodiments
of the present invention, the method includes the step of consuming
a composition that reduces body fat mass, leading to a change in
body composition.
[0025] Consuming components, such as those in a composition of
the present invention, while on a standardized diet, subjects lost
on average 45% more weight than a placebo group (Judy, W. V., "A
randomized double blind placebo controlled clinical trial evaluating
the effects of Glucotrim.RTM. containing 3% corosolic acid on weight
loss, lean and fat body mass, metabolic rate and blood sugar,"
SGTI protocol WLGT 0.03-2003, 2003) over the course of a clinical
trial employing an active ingredient of the composition. Additionally,
there was a corresponding reduction in the circumference of body
segments comprised of waist, hip, upper arm and thigh. Subjects
in the treatment group showed a 35% increase in total centimeters
lost relative to control groups. For example, the consumption of
the composition in accordance with the method of the present invention,
may allow a person's body to burn more or otherwise lose stored
body fat than they would otherwise burn or lose, leading to a reduction
in weight as well as reduction in body volume.
[0026] In one embodiment of the present invention, the method includes
the prior-to-sleep consumption of a combination, wherein the combination
includes one or more of, without being limited to, Banaba Leaf Extract
(containing 1%, 3%, or higher concentrations of Corosolic Acid),
Caffeine-free Green Tea Leaf Extract, N-olyl-phosphatidyl ethanolamine,
Caffeine-free White Tea Dry Leaf Extract, Caffeine-free Oolong Tea
Dry Leaf Extract, Chamomile, and Passionflower.
[0027] In a second embodiment of the present invention, the method
includes the upon-waking-from-sleep consumption of a combination,
wherein the combination includes one or more of, without being limited
to, Green Tea Leaf Extract, Anhydrous Caffeine, Banaba Leaf Extract
(containing 1%, 3%, or higher concentrations of Corosolic Acid),
Black Tea Leaf Extract, White Tea Leaf Extract, Oolong Tea Leaf
Extract, Rooibos Tea Powder, Vinpocetine, Coleus Forskholli Extract,
Theobroma Cacao Extract, and Evodia Rutaecarpa Fruit Extract.
[0028] In a third embodiment of the present invention, the method
comprises the prior-to-sleep consumption of a combination of one
or more, but not limited to Banaba Leaf Extract (containing 1%,
3%, or higher concentrations of Corosolic Acid), Green Tea Leaf
Extract, White Tea Leaf Extract and Oolong Tea Leaf Extract.
[0029] The supplement compositions according to the present invention,
may be utilized in methods to enhance weight loss by suppressing
appetite, preventing muscle protein catabolism, providing antioxidants
and inducing relaxation in a formulation designed to be taken immediately
prior to sleep. Another embodiment may be taken immediately upon
waking from sleep in the morning. The methods of the present invention
may be of particular interest to those seeking to lose body fat
mass. The method may involve a determination, and an administration,
of an amount of a composition in accordance with factors such as
the desired effect, the body weight and characteristics of the person
and the like. For example, in various embodiments, the method includes
administration of the aforementioned compositions to the diet of
a person on a daily basis.
[0030] Although the following examples illustrate the practice
of the present invention in three of its embodiments, the examples
should not be interpreted as limiting the scope of the invention.
Other embodiments of the present invention will be apparent to those
skilled in the art from consideration of the specification and example.
EXAMPLE 1
[0031] A diet supplement is provided in a soft-gel formulation
comprising Leaf Extract of Lagestroemia Speciosa (0.0240 g) standardized
to 3% Corosolic acid, Caffeine-free Green Tea dry leaf extract (0.0010
g) standardized to 45% EGCG, 75% Catechins, 90% Polyphenols, N-olyl-phosphatidyl
ethanolamine(NOPE)/EGCG blend (0.0010 g) standardized to 23% NOPE,
20% Polyphenols, 14% EGCG, Caffeine-free White Tea dry lead extract
(0.0010 g) standardized to 15% EGCG, 35% Catechins, 50% Polyphenols,
Caffeine-free Oolong Tea dry leaf extract (0.0010 g) standardized
to 15% EGCG, 35% Catechins, 50% Polyphenols, Chamomile (0.0010 g)
standardized to 1.2% Apigenin, and Passionflower (0.0010 g) supplying
3.5% flavanoids.
EXAMPLE 2
[0032] A diet supplement is provided utilizing a rapid release
technology formulation comprising Green Tea Leaf Extract (0.2000
g) standardized to 45% EGCG, 75% Catechins, 90% Polyphenols, Anhydrous
Caffeine (0.2000 g), Leaf Extract of Lagestroemia Speciosa (0.0240
g) standardized to 3% Corosolic acid, Black Tea Leaf Extract (0.0010
g) standardized to 25% EGCG, 50% Catechins, 70% Polyphenols, White
Tea Leaf Extract (0.0010 g) standardized to 15% EGCG, 25% Catechins,
50% Polyphenols, Oolong Tea Leaf Extract (0.0010 g) standardized
to 15% EGCG, 25% Catechins, 50% Polyphenols, Rooibos Tea Powder
(0.0010 g) standardized to 20% Polyphenols, Vinpocetine (0.0010
g), Coleus Forskholli Extract (0.0010 g) standardized to 10% Forskolin,
Theobroma Cacao Extract (0.0010 g) standardized to 6% Theobromine,
and Evodia Rutaecarpa Fruit Extract (0.0010 g) standardized to 10%
Evodiamine.
EXAMPLE 3
[0033] A diet supplement is provided in a soft-gel formulation
comprising Leaf Extract of Lagestroemia Speciosa (0.0240 g) standardized
to 3% Corosolic acid, Green Tea Leaf Extract (0.0010 g) standardized
to 18% EGCG, 26% Catechins, 45% Polyphenols, White Tea Leaf Extract
(0.0010 g) standardized to 13% EGCG, 22% Catechins, 40% Polyphenols,
Oolong Tea Leaf Extract (0.0010 g) standardized to 13% EGCG, 22%
Catechins, 40% Polyphenols, Safflower Oil, Fish Gelatin, Glycerin,
Yellow Beeswax, Purified Water, Titanium Dioxide, and Cochineal
Extract.
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