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Weight Loss Patent Abstract
Compositions and methods for administering to the diet of humans
a composition for inducing rapid weight loss, controlling appetite,
managing stress and supporting mental well-being, supporting relaxation,
and combating fatigue. A diet supplement comprising Calcium and
Potassium double salt of Garcinia Cambogia Extract supplying 60%
Hydroxycitric Acid, Gymnema Sylvestre Leaf Extract, Rhodiola Rosea
Root Extract, Theanine Astaxanthin Algae Extract, Chromium Polynicotinate,
Hoodia Gordonii, N-olyl-phosphatidyl ethanolamine (NOPE)/EGCG blend,
Vinpocetine, Russian Tarragon Extract, N-acetyl tyrosine, and Withania
Somnifera Root Extract is provided. Said diet supplement is comprised
of at least Hoodia Gordonii wherein the extract does not contain
any extract from the root of the plant.
Weight Loss Patent Claims
21. A method for promoting weight loss comprising the oral administration
to a mammal a dietary supplement comprising: Hoodia Gordonii or
an extract of Hoodia Gordonii; a Calcium and Potassium double salt
of Garcinia Cambogia Extract supplying 60% Hydroxycitric Acid; a
leaf extract of Gymnema Sylvestre; Chromium Polynicotinate; and
a blend of N-olyl-phosphatidyl Ethanolamine/EGCG, wherein the Hoodia
Gordonii or Hoodia Gordonii is devoid of material from the roots
of said Hoodia Gordonii.
22. The method of claim 21 wherein the dietary supplement further
comprises at least one ingredient selected from the group comprising
an extract of Russian Tarragon and Vinpocetine.
23. The method of claim 21, wherein the dietary supplement is administered
to the mammal at least once daily.
24. A method for promoting weight loss while concomitantly reducing
feelings of anxiety and stress in a mammal comprising the oral administration
to a mammal a dietary supplement comprising: Hoodia Gordonii or
an extract of Hoodia Gordonii; and an effective amount of Theanine,
wherein the Hoodia Gordonii or Hoodia Gordonii extract to devoid
any material from the roots of said Hoodia Gordonii.
25. The method of claim 24 wherein the dietary supplement further
comprises at least one ingredient selected from the group comprising
an extract of Rhodiola Rosea, N-acetyl Tyrosine and an extract of
Withania Somnifera Root wherein said at least one ingredient is
provided in an amount effective to aid in reducing feelings of anxiety
and stress in the mammal.
26. The method of claim 24 wherein the dietary supplement further
comprises an extract of Russian Tarragon wherein said Russian Tarragon
is provided in an amount effective to induce a feeling of relaxation
in the mammal.
27. The method of claim 24 wherein the dietary supplement further
comprises at least one ingredient selected from the group comprising
an extract of Algae providing Astaxanthin, and Vinpocetine wherein
said at least one ingredient is provided in an amount effective
to support mental well-being in the mammal.
28. The method of claim 24, wherein the dietary supplement is administered
to the mammal at least once daily.
Weight Loss Patent Description
RELATED APPLICATIONS
[0001] The application is related to and claims benefit of priority
to the Applicant's co-pending U.S. Provisional Patent Application
Ser. No. 60/691,945 entitled "Diet Supplement for Causing Rapid
Weight Loss, Controlling Appetite, Managing Stress, Supporting Relaxation,
Combating Fatigue and Supporting Mental Well-Being," filed
Jun. 17, 2006, the disclosure of which is hereby fully incorporated
by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to a diet supplement for causing
rapid weight loss, controlling appetite, managing stress, supporting
relaxation, combating fatigue and supporting mental well-being.
Preferably, the diet supplement is provided in a caplet form consumable
several times per day, for causing rapid weight loss, controlling
appetite, managing stress, supporting relaxation, combating fatigue
and supporting mental well-being throughout the day. Additionally,
the present invention relates to a method of promoting same by consuming
the diet supplement. In addition, the present invention relates
to a method of manufacturing the diet supplement.
SUMMARY OF THE INVENTION
[0003] The present invention provides for a diet supplement causing
rapid weight loss, controlling appetite, managing stress, supporting
relaxation, combating fatigue and supporting mental well-being.
The diet supplement may include one or more of the Calcium and Potassium
double salt of Garcinia Cambogia Extract standardized to about 60%
Hydroxycitric Acid, Gymnema Sylvestre Leaf Extract, Rhodioia Rosea
Root Extract, Theanine (gamma-glutamylethylamide). Astaxanthin,
Chromium Polynicotinate, Hoodia Gordonii (e.g., an extract that
does not contain any extract from the root of the plant), N-olyl-phosphatidyl
ethanolamine (NOPE)/EGCG blend, Vinpocetine, Russian Tarragon Extract
(Artemisia dracunculus L. plant). N-acetyl tyrosine and Withania
Somnifera Root Extract. For example, in an embodiment, the present
invention may provide a diet supplement comprising an extract of
Hoodia Gordonii and Vinpocetine, wherein the Hoodia Gordonii extract
does not contain any extract from the roots of the plant. The diet
supplement may also include any one or more of an extract of Rhodiola
Rosea, Theanine, an Astaxanthin extract of Algae, Chromium Polynicotinate,
a blend of N-olyl-phosphatidyl ethanolamine/EGCG Blend, an extract
of Russian Tarragon, N-acetyl tyrosine, an extract of Withania Somnifera,
an extract of Gymnema Sylvestre, and the Calcium and Potassium double
salt of Garcinia Cambogia Extract supplying about 60% Hydroxycitric
Acid.
[0004] Advantageously, the diet supplement is provided in a caplet
form, which may be consumed several times per day. For instance,
in an embodiment, the diet supplement comprises a two caplet serving;
each serving suitable for being consumed three times daily, e.g.,
before each one of three daily meals. In this manner, the diet supplement
may cause rapid weight loss, control appetite, manage stress, support
relaxation, combat fatigue and support mental well-being for an
extended period of time, e.g., all day.
[0005] The present invention also provides, by the consumption
of the supplemental composition, a method for causing rapid weight
loss, controlling appetite, managing stress, supporting relaxation,
and supporting mental well-being. For example, in an embodiment,
the present invention may provide a method for controlling appetite
and promoting rapid weight loss, comprising the step of administering
to a human or animal a diet supplement that comprises an extract
of Hoodia Gordonii, wherein the Hoodia Gordonii extract does not
contain any extract from the roots of the plant, and may also comprise
one or more of the Calcium and Potassium double salt of Garcinia
Cambogia Extract supplying 60% Hydroxycitric Acid. Gymnema Sylvestre,
Chromium Polynicotinate, N-olyl-phosphatidyl Ethanolamine/EGCG Blend,
an extract of Russian Tarragon and Vinpocetine. The method may include
the step of administering the diet supplement to a human or animal
at least once daily.
[0006] In addition, the present invention relates to a method of
manufacturing a diet supplement for causing rapid weight loss, controlling
appetite, managing stress, supporting relaxation, combating fatigue
and supporting mental well-being. In an embodiment, there is provided
a method of manufacturing a diet supplement comprising one or more
of the Calcium and Potassium double salt of Garcinia Cambogia Extract
standardized to about 60% Hydroxycitric Acid, Gymnema Sylvestre
Leaf Extract, Rhodiola Rosea Root Extract, Theanine (gamma-glutamyethylamide),
Astaxanthin, Chromium Polynicotinate, Hoodia Gordonii (e.g., an
extract that does not contain any extract from the root of the plant),
N-olyl-phosphatidyl ethanolamine (NOPE/EGCG blend, Vinpocetine,
Russian Tarragon Extract (Artemisia dracunculus L. plant), N-acetyl
tyrosine and Withania Somnifera Root Extract.
[0007] In addition, the present invention may relate to a method
of managing stress comprising the step of administering to a human
or animal a diet supplement that comprises an extract of Rhodiola
Rosea, Theanine, N-acetyl Tyrosine and an extract of Withania Somnifera
Root. In addition, the present invention may relate to a method
of supporting relaxation comprising the step of administering to
a human or animal a diet supplement that comprises Theanine and
an extract of Russian Tarragon. In addition, the present invention
may relate to a method of supporting mental well-being comprising
the step of administering to a human or animal a diet supplement
that comprises an extract of Rhodiola Rosea, Theanine, Astaxanthin
extract of Algae, Vinpocetine, N-acetyl Tyrosine and an extract
of Withania Somnifera Root. In addition, the present invention may
relate to a method of ameliorating mental performance comprising
the step of administering to a human or animal a diet supplement
that comprises Vinpocetine, an extract of Rhodiola Rosea, and N-acetyl
Tyrosine. In addition, the present invention may relate to a method
of regulating blood glucose levels comprising the step of administering
to a human or animal a diet supplement that comprises an extract
of Gymnema Sylvestre, Chromium Polynicotinate, and an extract of
Russian Tarragon. In addition, the present invention may relate
to a method of supplying antioxidants to a human or animal comprising
the step of administering to a human or animal a diet supplement
that comprises an extract of Rhodiola Rosea, Theanine, an extract
of Astaxanthin, N-olyl-phosphatidyl Ethanolamine/EGCG Blend, and
an extract of Withania Somnifera Root.
DETAILED DESCRIPTION OF THE INVENTION
[0008] The present invention, according to various embodiments
thereof, is directed to a diet supplement for inducing rapid weight
loss, controlling appetite, and managing stress, supporting relaxation,
combating fatigue and supporting mental well-being.
[0009] Hoodia Gordonii (wherein the extract does not contain any
extract from the root of the plant).
[0010] Hoodia is a cactus which has been used traditionally to
ease hunger discomfort and as such, is used as an appetite suppressant.
A suspected active compound isolated from Hoodia Root, termed P57,
has been shown to reduce food intake in rats (MacLean D B. Luo L
G. Increased ATP content/production in the hypothalamus may be a
signal for energy-sensing of satiety, studies of the anorectic mechanism
of a plant steroidal glycoside. Brain Res. 2004 Sep 10; 1020(1-2):1-11.).
Furthermore, it was found that P57 countered the reduction in ATP
normally expected from calorie restriction. Further studies in rats
indicate that Hoodia is effective in reducing blood glucose and
weight loss (Tulp O L, Harbl N A, Mihalov J, DerMarderosian A. Effect
of Hoodia plant on food intake and body weight in lean and obese
LA/Ntul//cp rats. FASEB J. 2001 Mar 7, 15(4):A404.: Tulp O L Harbi
N A, DerMarderosian A. Effect of Hoodia plant on weight loss in
congenic obese LA/Ntul//-cp rats FASEB J. 2002 Mar 20:16(4):A648.).
[0011] In 2001, Phytopharm completed a double-blind, placebo-controlled
trial comprised of a group of health yet overweight volunteers.
Following two weeks of high doses of Hoodia, the treatment group
showed a reaction in weight while being inactive, and further, their
daily caloric intake was voluntarily reduced via appetite suppression
by approximately 1000 calories.
[0012] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Hoodia Gordonii (e.g., an extract that does not contain any extract
from the root of the plant). A serving of the diet supplement may
include from about 1.0 mg to about 100 mg of Hoodia Gordonii (e.g.,
an extract that does not contain any extract from the root of the
plant). The preferred dosage, in a serving of said diet supplement,
comprises about 20 mg of Hoodia Gordonii (e.g., an extract that
does not contain any extract from the root of the plant).
[0013] Vinpocetine
[0014] Vinpocetine is an extract of Vinca minor, or periwinkle
plant, used traditionally to improve circulation. Vinpocetine has
been shown to prevent brain cell damage by increasing blood flow
in a rat model of forebrain ischemia (2-vessel occlusion and hypotension)
wherein the ischemia was maintained for 10 minutes (Sauer D, Rischke
R, Beck T, Rossberg C, Mennel H D, Bielenberg G W, Kriegistein J,
Vinpocetine prevents ischemic cell damage in rat hippocampus. Life
Sci. 1998: 43(21).17333-9). Image analysis indicates that Vinpocetine
can increase cerebral blood flow in stroke patients and thereby
improving cerebral glucose uptake and metabolism in the brain (Szakail
S, Boros I, Balkay L, Emri M, Fekete I, Kerenyi L, Lehel S, Marian
T, Molnar T, Varga J, Galuska L, Tron L, Bereczki D, Csiba L, Gulyas
B, Cerebral effects of a single dose of intravenous vinpocetine
in chronic stroke patients; a PET study. J Neuroimaging. 1998 Oct;8(4):197-204:
Szilagyi G, Nagy Z, Balkay L, Boros I, Emri M, Lehel S, Marian T,
Moinar T, Szakail S, Tron L, Bereczki D, Csiba L, Fekete I, Kerenyi
L, Galuska L, Varga J, Bonoczk P, Vas A, Gulyas B. Effects of vinpocetine
on the redistribution of cerebral blood flow and glucose matabolism
in chronic ischemic stroke patients; a PET study. J Neurol Sci 2005
Mar 15:229-230:275-84). Interestingly, Vinpocetine may exert its
effect by blocking sodium channels in the brain (Moinar P, Erdo
S L. Vinpocetine is as potent as phenyloin to block voltage-gated
Na+ channels in rat cortical neurons. Eur J Pharmacol 1995 Feb 6:273(3):303-6),
which is thought to be involved in neuroprotection (Bonoczk P, Gulyas
B, Adam-Vizi V, Nemes A, Karpali E, Kiss B, Kapas M, Szantay C,
Koncz I, Zelles T, Vas A, Role of sodium channel inhibition in neuroprotection
effect of vinpocetine. Brain Res Bull, 2000 Oct: 53(3):245-54).
The antioxidant activity of Vinpocetine may also contribute to protection
of neural cells (Santos M S, Duarte A I, Moreira P I, Oliveira C
R, Synaptosomal response to oxidative stress effect of vinpocetine.
Free Radic Res. 2000 Jan; 32(1):57-66.). Furthermore, Vinpocetine
may also prevent the accumulation of calcium, phosphorus and aluminum
in the central nervous system, which has been suggested to be involved
in atherosclerosis (Yasui M, Yano I, Ota K, Oshima A, Calcium phosphorus
and aluminum concentrations in the central nervous system, liver
and kidney of rabbits with experimental atherosclerosis preventive
effects of vinpocetine on the deposition of these elements, J Int
Med Res 1990 Mar-Apr: 18(2):142-52.).
[0015] In human trials, Vinpocetine has been shown to be effective
at treating a number of circulation-related disorders. In a double-blind
clinical trial, Vinpocetine was shown to effect significant improvement
in elderly patients with chronic cerebral dysfunction (Balestreri
R, Fontana L, Astengo F. A double-blind placebo controlled evaluation
of the safety and efficacy of vinpocetine in the treatment of patients
with chronic vascular senile cerebral dysfuction. J Am Geriatr Soc
1987 May, 35(6):425-30). A single-blind randomized trial has demonstrated
the feasibility of continued study of Vinpocetine to treat stroke
patients (Feigin V L, Doronin B M, Popova T F, Gribatcheva E V,
Tchervov D V. Vinpocetine treatment in acute ischaemic stroke; a
pilot single-blind randomized clinical trial. Eur J Neurol 2001
Jan; 8(1):81-5.). Further to these studies, it was shown that cognitive
performance improved in patients with mild to moderate pychosyndromes
such as dementia (Hindmarch I, Fuchs H H, Erzigkeit H. Efficacy
and tolerance of vinpocetine in ambulant patients suffering from
mild to moderate organic psychosyndromes Int Clin Psychopharmacol.
1991 spring;6(1):31-43.). An improvement in the memory of healthy
woman due to a three-day supplementation with Vinpocetine has also
been documented (Subhan Z, Hindmarch I. Psychopharmacological effects
of vinpocetine in normal healthy volunteers. Eur J Clin Pharmacol.
1985:28(5):567-71).
[0016] In an embodiment of the present invention which is set forth
in greater detail in Example 1, include from about 0.1 mg to about
10 mg of Vinpocetine. The preferred dosage, in a serving of said
diet supplement, comprises about 1 mg of Vinpocetine.
[0017] Theanine (Gamma-Glutamylethylamide)
[0018] Theanine is an amino acid found in green tea. It is however
distinct from the polyphenols and Catechins that are typically associated
with the beneficial effects of green tea. While Catechins are generally
associated with antioxidant activity, Theanine is associated with
anti-stress and cortisol control.
[0019] In hypertensive rats, Theanine has been shown to lower blood
pressure (Yokogoshi H, Kato Y, Sagesaka Y M, Takinara-Matsuura T,
Kakuda T, Takeuchi N. Reduction effect of theanine on blood pressure
and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci
Biotechnol biochem. 1995 Apr;59(4):615-8). Moreover, Theanine possess
neuroprotective effects in animal models of brain damage (Kakuda
T, Yanase H, Utsunomlya K, Nozawa A, Unno T, Kataoka K. Protective
effect of gamma-glutamylethylamide (Theanine) on ischemic delayed
neuronal death in gerbils. Neurosci Lett. 2000 Aug 11;289(3):189-92.)
which is thought to be due to inhibiting the ligand binding to glutamate
receptors (Kakuda T, Nozawa A, Sugimoto A, Niino H. Inhibition by
theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519
glutamate receptors. Biosci Biotechnol Biochem. 2002 Dec:66(12):2683-6.).
Glutamic acid signaling through its related glutamate receptor is
involved in memory and learning. Excess glutamate receptor signaling,
which may occur due to and following brain injury, can lead to neuronal
cell death (Chol D W, Rothman S M. The role of glutamate neurotoxicity
in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990:13:171-82.)
via apoptotic cascade mechanisms. Furthermore, weight gain and fat
accumulation have been suppressed in rats fed Theanine (Zheng G,
Sayama K, Okubo T, Juneja L R, Oguni I, Anti-obesity effects of
three major components of green tea, catechins, caffeine and theanine,
in mice. In Vivo 2004 Jan-Feb:18(1):56-62.) relative to control
animals.
[0020] Clinical studies have been done examining effects of Theanine
in humans. One study demonstrated a relaxing effect under non-stress
conditions (Lu K, Gray M A, Oliver C, Liley D T, Harrison B J, Bartholomeusz
C F, Phan K L, Nathan P J. The acute effects of L-theanine in comparison
with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol,
2004 Oct;19(7):457-65.).
[0021] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Theanine (gamma-glutamylethylamide). A serving of the diet supplement
may include from about 1.0 mg to about 100 mg of Theanine (gamma-glutamylethylamide).
The preferred dosage, in a serving of said diet supplement, comprises
about 52 mg of Theanine (gamma-glutamylethylamide).
[0022] Astaxanthin
[0023] Astaxanthin is a red carontenoid pigment occurring naturally
in many living organisms. Studies utilizing animals indicate that
Astaxanthin can confer antioxidant activity that can altenuate exercise-induced
muscle damage (Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Macka
T, Toyokuni S, Oka S, Yasuhara M, Yoshikawa T. Astaxanthin limits
exercise-induced skeletal and cardiac muscle damage in mice. Antioxid
Redox Signal 2003 Feb:5(1):139-44), has anticancer activity (Jyonouchi
H, Sun S, Lijima K, Gross M D. Antitumor activity of astaxanthin
and its mode of action. Nutr Cancer. 2000:36(1):59-65). anti-inflammatory
activity (Kurashige M, Okimasu E, Inoue M, Utsumi K. Inhibition
of oxidative injury of biological membranes by astaxanthin. Physiol
Chem Phys Med NMR 1990:22(1);27-38.). anti-diabetic activity (Uchiyama
K, Naito Y, Hasegawa G, Nakamura N, Takahashi J, Yoshikawa T. Astaxanthin
protects beta-cells against glucose toxicity in diabetic db/db mice.
Redox Rep 2002:7(5):290-3.), immunity-boosting properties (Okai
Y, Higashi-Okai K. Possible immunomodulating activities of carotenoids
in vitro cell culture experiments Int J Immunopharmacol. 1996 Dec;18(12):753-8.),
and antihypertensive and neuroprotective properties (Hussein G,
Nakamura M, Zhao Q, Iguchi T, Goto H, Sankawa U, Watanabe H. Antihypertensive
and neuroprotective effects of astaxanthin in experimental animals.
Biol Pharm Bull. 2005 Jan;28(1):47-52.).
[0024] Studies have examined the effects of Astaxanthin in humans
where it has been shown to be safe (Spiller G A, Dewell A. Safety
of an astaxanthin-rich Haematococcus pluvialis algal extract, a
randomized clinical trial. J Med Food 2003 spring;6(1);51-6.) and
of potential benefit in cancer treatment by inhibiting 5-alpha-reductase
(Anderson M L. A preliminary investigation of the enzymatic inhibition
of 5alpha-reduction and growth of prostatic carcinoma cell line
LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract
in vitro. J Herb Pharmacother, 2005;5(1);17-26.).
[0025] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Astaxanthin. A serving of the diet supplement may include from about
1 mg to about 100 mg of Astaxanthin. The preferred dosage, in a
serving of said diet supplement, comprises from about 5 mg of Astaxanthin.
[0026] Chromium Polynicotinate
[0027] Chromium is an essential trace mineral that is used to control
blood sugar levels by aiding insulin binding, wherein it can aid
in the control weight of reduction. Chromium, however, is poorly
absorbed by the body and must therefore be combined with a more
efficiently absorbed compound such as niacin (found in Polynicotinate).
Chromium likely exerts its main function as a component of the glucose
tolerance factor, which is involved in insulin sensitivity.
[0028] Chromium has been shown clinically to increase lean mass
(Bahadori B, Wailner S, Schneider H, Wascher T C, Toplak H, Effect
of chromium yeast and chromium picolinate on body composition of
obese, non-diabetic patients during and after a formula diet. Acta
Med Austriaca, 1997:24(5):185-7.) and reduce body fat when combined
with exercise (Grant K E, Chandler R M, Castle A L, Ivy J L, Chromium
and exercise training; effect on obese women, Med Sci Sports Exerc.
1997 Aug:29(8:992-8.). Chromium has also been shown to increase
HDL, (`good`) cholesterol (Riales R, Albrink M J. Effect of chromium
chloride supplementation on glucose tolerance and serum lipids including
high-density lipoprotein of adult men Am J Clin Nutr 1981:34:2670-8.).
[0029] In an embodiment of the present invention which is set forth
in greater detail in Example 1, the diet supplement may include
Chromium Polynicotinate. A serving of the diet supplement may include
from about 0.01 mg to about 10 mg of Chromium Polynicotinate. The
preferred dosage, in a serving of said diet supplement, comprises
about 0.133 meg (0.000133 g) of Chromium Polynicotinate.
[0030] N-olyl-Phosphatidyl Ethanolamine ("NOPE")/EGCG
Blend
[0031] NOPE is a naturally occuring lipid synthesized and released
in the intestine, in vivo rat studies have shown that food deprivation
results in decreased NOPE synthesis, while administration of NOPE
causes appetite suppression and subsequent weight loss (Rodriguez
de Fonseca F, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Munillo-Rodriguez
E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, Piomelli
D. An anorexic lipid mediator regulated by feeding Nature 2001 Nov
8;414(6860):209012., Gaetani S, Oveisi F, Piomelli D. Modulation
of meal pattern in the rat by the anorexic lipid mediator olecylethanolamide.
Neuropsychopharmacology, 2003 Jul;28(70:1311-6.). Moreover, NOPE
has been shown to lower body weight in obese rats (Fu J, Oveisi
F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous
PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese
rats. Neuropharmacology, 2005 Jun;48(8):1147-53.). This action is
likely mediated through the NOPE binding of the peroxisome-proliferator-activated
receptor-alpha (PPAR-alpha) (Fu J, Gaetani S, Oveisi F, Lo Verme
J, Serrano A, Rodriguez De Fonseca F, Rosengarth A, Luecke H, Di
Giacomo B, Tarzia G, Piomelli D. Oleylethanolamide regulates feeding
and body weight through activation of the nuclear receptor PPAR-alpha
Nature 2003 Sep 4;425(6953):90-3.). PPAR-alpha is involved in regulating
lipid metabolism (Chawla A, Repa J J, Evans R M, Mangeisdorf D J.
Nuclear receptors and lipid physiology: opening the X-files. Science
2001 Nov 30:294(5548):1866-70.). Furthermore, another possible mechanism
of NOPE's action is through the 7-transmembrane spanning G protein-coupled
receptor (GPCR) GPR119 found predominantly in human and rodent pancreas
(Overton H A, Babbs A J, Doel S M, Fyfe M C, Gardner L S, Griffin
G, Jackson H C, Procter M J, Rasamison C M, Tang-Christensen M,
Widdowson P S, Williams G M, Reynet C, Deorphanization of a G protein-coupled
receptor for oleoylethanoiamide and its use in the discovery of
small-molecule hypophagic agents. Cell Metab. 2006 Mar;3(3):167-75.)
by which hypophagic signals may be conferred.
[0032] (-)-Epigallocatechin-3-gallate (EGCG) is the most active
Catechin polyphenol compound found in Green Tea. EGCG has potent
antioxidant activity and has been shown by laboratory tests to be
greater than many well known and established antioxidants such as
vitamin C and E (Pillar S P, Mitscher L A, Menon S R, Pillal C A.
Shankel D M. Antimutagenic/antioxidant activity of green tea components
and related compounds. J Environ Pathol Toxicol Oncol. 1999:18(3):147-58).
Further to its antioxidant activity, EGCG was found to be effective
at reducing food intake, body weight, cholesterol and triglycerides
in both lean and obese rats (Kao Y H, Hipakka R A, Liao S. Modulation
of endocrine systems and food intake by green tea epigailocatechin
gailate. Endocrinology,2000 Mar;141(3):980-7.). In humans, Green
Tea extracts rich in EGCG and other Catechins have been shown to
result in a rapid increase in plasma antioxidant activity (Benzie
I F, Szeto Y T, Strain J J, Tomlinson B. Consumption of green tea
causes rapid increase in plasma antioxidant power in humans, Nutr
Cancer 1999:34(1):83-7.) and further to aid in weight loss due to
increased metabolism and fat oxidation (Chantre P, Lairon D. Recent
findings of green tea extract AR25 (Exolise) and its activity for
the treatment of obesity. Phytomedicine 2002 Jan;9(1):3-8. Dulico
A G, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P,
Vandermander J. Efficacy of a green tea extract rich in catachin
polyphenols and caffeine in increasing 24-h energy expenditure and
fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5.).
The associated mechanism of action may be, at least partially, due
to an increase in norepinephrine. Catechins are also known to inhibit
catechol-O-methyl-transferase (COMT), an enzyme that degrades norepinephrine
(Borchardt R T, Huber J A, Catechol O-methyltransferase, 5. Structure-activity
relationships for inhibition by flavonoids. J Med Chem, 1975 Jan;18(1):120-2.).
EGCG is both a substrate of and, as a result an inhibitor of, COMT
(Li C, Allen A, Kwagh J, Doliba N M, Qin W, Najafi H, Collins H
W, Matschinsky F M, Stanley C A, Smith T J. Green tea polyphenols
modulate insulin secretion by inhibiting glutamate dehydrogenase.
J Biol Chem. 2006 Apr 14:281(15:10214-21. Epub 2006 Feb 13). In
turn, norepinephrine inhibits degradation of intracellular cyclic
AMP (cAMP), an important signaling molecule involved in many metabolic
processes including thermogenesis. Furthermore, EGCG has been shown
to be an inhibitor of glutamate dehydrogenase, which regulates insulin
secretion (Lu H, Meng X, Yang C S. Enzymology of methylation of
tea catechins and inhibition of catechol-O-methyltransferase by
(-)-epigallocatechin gailate. Drug Metab Dispos. 2003 May:31(5):572-9.).
[0033] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
an N-olyl-phosphatidyl ethanolamine ("NOPE")/EGCG blend.
A serving of the diet supplement may include from about 0.1 mg to
about 10 mg of N-olyl-phosphatidyl ethanolamine (NOPR)/EGCG blend.
The preferred dosage, in a serving of said diet supplement, comprises
about 1 mg of N-olyl-phosphatidyl ethanolamine (NOPE)/EGCG blend.
[0034] Russian Tarragon Extract
[0035] Russian Tarragon (Artemisia dracunculus) is a perennial
herb widely used in cooking. Historically it has been use as a natural
blood cleanser and as a treatment for headaches and dizziness. Current
studies are examining the use of the ethanolic extract of Russian
Tarragon called for the treatment of hyperglycemia associated with
diabetes. The toxicology of this extract has been evaluated, and
shown to be safe and non-toxic (Ribnicky D M, Poulev A, O'Neal J,
Wnorowski G, Malek D E, Jager R, Raskin I. Toxicological evaluation
of the ethanolic extract of Artemisia dracunculus L. for use as
a dietary supplement and in functional foods. Food Chem Toxicol
2004 Apr;42(4):586-98). Furthermore, it has been demonstrated to
reduce blood glucose levels in diabetic mice (Ribnicky D M, Poulev
A, Watford M, Cefalu W T, Raskin I. Antihyperglycemic activity of
Tarralin.TM., an ethanolic extract of Artemisia dracunculus L. Phytomedicine.
In Press. Corrected Proof, Available online 2 November 2005). Additionally,
an essential oil extracted from Artemisia dracunculus may have potential
therapeutic effects as an anticonvulsant and mild sedative (Sayyah
M, Nadjafnia L, Kamalinejad M. Anticonvulsant activity and chemical
composition of Artemisia dracunculus L. essential oil J Ethnopharmacol
2004 Oct.94(2-3):283-7.).
[0036] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Russian Tarragon Extract (Artemisia dracunculus L. plant). A serving
of the diet supplement may include from about 0.1 mg to about 10
mg of Russian Tarragon Extract (Artemisia dracunculus L. plant).
The preferred dosage, in a serving of said diet supplement, comprises
about 1 mg of Russian Tarragon Extract (Artemisia dracunculus L.
plant).
[0037] N-acetyl Tyrosine
[0038] N-acetyl tyrosine is a stable form of the amino acid tyrosine.
Tyrosine is a nonessential amino acid, meaning that it can be synthesized
by the body. Amino acids are the building blocks of protein. Tyrosine
can also function as a neurotransmitter precursor and is converted
into neuronal signaling molecules such as dopamine, norepinephrine,
and epinephrine. It is known that increasing levels of neurotransmitter
precursors in the brain stimulates further neurotransmitter production
(Wurtman R J, Hefti F, Melamed E. Precursor control of neurotransmitter
synthesis. Pharmacol Rev. 1980 Dec:32(4)315-35). As such, Tyrosine
levels in the brain and the subsequent conversion into neurotransmitter
has been shown to increase in response to increased dietary Tryrosine
(Fernstrom J D, Fernsstrom M H. Dietary effects on tyrosine availability
and catecholamine synthesis in the central nervous system, possible
relevance to the control of protein intake. Proc Nutr Soc. 1994
Jul:53(2):419-29.). Conversely. Tyrosine depletion in humans has
been shown to have detrimental effects on mood (Leyton M, Young
S N, Pihl R O, Elezadi S, Lauze C, Blier P, Baker G B, Benkelfat
C. Effects on mood of acute phenylalanine/tyrosine depletion in
healthy women. Neuropsychopharmacology 2000 Jan:22(1):52-63.) and
cognitive performance (Grevet E H, Tietzmann M R, Shansis F M, Hasteripflugl
C, Santana L C, Forster L, Kapczinskil F, Irquierdo I. Behavioural
effects of acute phenylalanine and tyrosine depletion in healthy
male volunteers. J Psychopharmacol, 2000 Mar;16(1:51-5.).
[0039] Tyrosine supplementation has be used to successfully improve
mood and cognitive performance during periods of stress (Banderet
L E, Liebeman H R Treatment with tyrosine a neurotransmitter precursor,
reduces environmental stress in humans. Brain Res Bull 1989 Apr:22(4):759-62).
One study has demonstrated a reduction in blood pressure in addition
to cognitive improvement (Deijen J B, Oriebeke J F. Effect of tyrosine
on cognitive function and blood pressure under stress. Brain Res
Bull 1994:33(3):319-23.) via Tyrosine supplementation. Mental performance
during fatigue has been shown to improve with increased Tyrosine
(Neri D F, Wiegmann D, Stanny R R, Shappell S A, McCardie A, McKay
D L. The effects of tyrosine on cognitive performance during extended
wakefulness. Aviat Space Environ Med. 1995 Apr:68(4):313-9.) supplementation.
[0040] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
N-acetyl tyrosine. A serving of the diet supplement may include
from about 0.1 mg to about 10 mg of N-acetyl tyrosine. The preferred
dosage, in a serving of said diet supplement, comprises about 1
mg of N-acetyl tyrosine.
[0041] Gymnema Sylvestre
[0042] Gymnema Sylvestre is a plant which is used in traditional
Eastern medicine as a treatment for diabetes due to its ability
to inhibit glucose absorption in addition to its ability suppress
the taste of `sweetness`.
[0043] Gymnema extract has been shown to be an effective diabetes
treatment in rats (Okabayashi Y, Tani S, Fujisawa T, Koide M, Hasegawa
H, Nakamura T, Fujii M, Otsuki M. Effects of Gymnema sylvestre R.Br
on glucose homeostasis in rats Diabetes Res Clin Pract. 1990 May-Jun:9(2):143-8.).
This is likely due to the ability of Gymnema to suppress glucose
absorption in rat intestine (Shimizu K, Iino A, Nakajima J, Tanaka
K, Nakalyo S, Urakawa N, Atsuchi M, Wada T, Yamashita C, Suppression
of glucose absorption by some fractions extracted from Gymnema sylvestre
leaves J Vet Med Sci. 1997 Apr:59(4):245-51); to lower glucose content
in tissue of rats (Chattopadhyay R R. Possible mechanism of antihyperglycemic
effect of Gymnema sylvestre leaf extract, part I Gen Pharmacol 1998
Sep;31(3):495-6.); and to suppress neural responses to sweet taste
in rats and mice (Imoto T, Miyasaka A, Ishima R, Akasaka K. A novel
peptide isolated from the leaves of Gymnema sylvestre-I. Characterization
and its suppressive effect on the neural responses to sweet taste
stimuli in the rat Comp Biochem Physiol A 1991;100(2):309-14. Ninomiya
Y, Imoto T. Gurmarin inhibition of sweet taste responses in mice.
Am J Physiol. 1995 Apr;268(4 Pt 2),R1019-25.).
[0044] Moreover, Gymnema has further been shown to be effective
in treating diabetes in humans by both lowering blood glucose along
with increasing insulin levels (Shanmugasundaram E R, Rajeswari
G, Baskaran K, Rajesh Kumar B R, Radha Shanmugasundaram K, Kizar
Ahmath B. Use of Gymnema sylvestre leaf extract in the control of
blood glucose in insulin-dependent diabetes melitus J Ethnopharmacol
1990 Oct;30(3):281-94; Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram
K, Shanmugasundaram E R. Antidiabetic effect of a leaf extract from
Gymnema sylvestre in non-insulin-dependent diabetes melitus patients.
J Ethnopharmacol. 1990 Oct;30(3):295-300.). Gymnema Sylvestre extract
can be combined with HCA to produce greater weight loss (Preuss
H G, Garis R I, Bramble J D, Bagchi D, Bagchi M, Rao C V, Satyanarayana
S. Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric
acid in weight control Int J Clin Pharmacol Res 2005;25(3):133-44.)
as experimentally evidenced.
[0045] In an emodiment of the present invention, which is set forth
in greater detail in Example 1, the diet supplement may include
Gymnema Sylvestre Leaf Extract. A serving of the diet supplement
may include from about 1 mg to about 1000 mg of Gymnema Sylvestre
Leaf Extract. The preferred dosage, in a serving of said diet supplement,
comprises about 133 mg of Gymnema Sylvestre Leaf Extract.
[0046] Withania Somnifera Root Extract
[0047] Withania Somnifera (Ashwagandha Winter Cherry) is an herb
used in traditional East Indian medicine. Withania Somnifera is
reported to have a number of beneficial effects including antioxidant
and antistress (Mishra L C, Singh B B, Dagenais S. Scientific basis
for the therapeutic use of Withania somnifera (ashwagandha); a review
Altern Med Rev. 2000 Aug:5(4):334-46) activities. It is also considered
to be an adaptogen and therefore, may possess non-specific protective
effects, wherein this has been demonstrated in animal studies (Dhuley
J N. Asaptogenic and cardioprotective action of ashwagandha in rats
and frogs J Ethnopharmacol. 2000 Apr;70(1):57-63.). In rats, Withania
Somnifera has a positive effect on mood by reducing stress and anxiety
(Bhattacharya S K, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant
activity of Witharia somnifera glycowithanolides, an experimental
study. Phytomedicine 2000 Dec;7(6):463-9.). Moreover, Withania Somnifera
has been shown to attenuate both age-associated and chemica-induced
cellular and tissue oxidative damage in rats (Gupia S K, Dua A,
Vohra B P. Withania somnifera (Ashwagandha) attenuates antioxidant
defense in aged spinal cord and inhibits copper induced lipid peroxidation
and protein oxidative modifications Drug Metabol Drug Interact,
2003:19(3):211-22.).
[0048] Human clinical trials examining Withania Somnifera have
been conducted. One clinical trial demonstrated potential for Withania
Somnifera to treat arthritic (Kuikami R R, Patki P S, Jog V P, Gandage
S G, Patwardhan B, Treatment of osteoarthritis with a herbomineral
formulation, a double-blind, placebo-controlled, cross-over study
J Ethnopharmacol, 1991 May-Jun;33(1-2):91-5).
[0049] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Withania Somnifera Root Extract. A serving of the diet supplement
may include from about 0.1 mg to about 10 mg of Withania Somnifera
Root Extract. The preferred dosage, in a serving of said diet supplement,
comprising about 1 mg of Withania Somnifera Root Extract.
[0050] Calcium and Potassium double salt of Garcinia Cambogis Extract
(supplying about 60% Hydroxycitric Acid)
[0051] Hydroxycitric acid (HCA) is extracted from the fruit of
the Garcinia Cambogia plant, it has been shown to inhibit fat production
and suppress appetite and as such is used to control weight by virtue
of these characteristics.
[0052] U.S. Pat. No. 6,875,891, entitled "Process for Preparing
Highly Water Soluble Double Salts of Hydroxycitric Acid Particularly
Alkali and Alkaline Earth Metal Double Salts" describes a method
for producing highly water-soluble Calcium and Potassium Hydroxycitric
Acid salts which are odorless and essentially tasteless. The process
involves the steps of precipitating sparingly soluble alkaline earth
metal salts of Hydroxycitric acid from an aqueous extract of plants
belonging to the Garcinia species, dissolving said alkaline earth
metal salts in aqueous alkali and adjusting the pH of said alkaline
solution by adding an extract of purified Garcinia fruit extract.
From this process, the Calcium salt of Hydroxycitric Acid can be
precipitated. Additionally, said Calcium salt can be treated with
Potassium Hydroxide to form the Potassium and Calcium double salt
of Hydroxycitric Acid which can further be purified by treatment
with activated charcoal, filtered and spray dried.
[0053] HCA has been shown to inhibit fatty acid synthesis and repress
appetite in rats (Watson J A, Fang M, Lowenstein J M. Tricarballylate
and hydroxycitrate: substrate and inhibitor of ATP citrate oxaloacetate
lyase Arch Biochem Biophys 1969 Dec;135(1):209-17. Louter-van de
Haar J, Wielinga P Y, Scheurink A J. Nieuwenhuizen A G. Comparison
of the effects of three different (-)-hydroxycitric acid preparations
on food intake in rats Nutr Metal (Lond), 2005 Sep 13:2:23.) and
is known to be a competitive inhibitor or ATP citrate lyase, an
enzyme necessary for the conversion of carbohydrates into fat. By
its actions of competitive inhibition of ATP citrate lyase, it reduces
that amount of storable fat. Garcinia Cambogia extract can also
improve glucose metabolism in mice (Hayamizu K, Hirakawa H, Oikawa
D, Nakanishi T, Takagi T, Tachibana T, Furuse M. Effects of Garcinia
cambogia extract on serum leptin and insulin in mice, Fitoterapia,
2003 Apr:74(3:267-73).
[0054] Several human clinical trials have demonstrated that the
HCA extract of Garcinia Cambogia can be used safely and has beneficial
effects in terms of weight management, Moreover, HCA has been shown
to reduce caloric intake (Westerterp-Plantenga M S, Kovacs E M.
The effect of (-)-hydroxycitrate on energy intake and safety in
overweight humans Int J Obes Relat Metab Disord. 2002 Jun;26(6):870-2)
and increase fat oxidation during exercise in untrained men and
women (Lim K, Ryu S, Nho H S, Choi S K, kwon T, Suh H, So J, Tomita
K, Okuhara Y, Shigematsu N. (-)-Hydroxycitric acid ingestion increases
fat utilization during exercise in untrained women J Nutr Sci Vitaminol
(Tokyo) 2003 Jun;49(3):163-7: Tomita K, Okuhara Y, Shigematsu N,
Suh H, Lim K (-)-hydroxycitrate ingestion increases fat oxidation
during moderate intensity exercise in untrained men. Biosci Biotechnol
Biochem, 2003 Sep;67(9):1999-2001.). The results of a randomized
controlled trial which combined data from two earlier trials demonstrated
that daily HCA and chromium supplementation together with moderate
exercise over an 8-week period resulted in increased weight loss
as compared to placebo, as well as resulted in an improved blood
cholesterol profile (Preuss H G, Garis R I, Bramble J D, Bagchi
D, Bagchi M, Rao C V, Satyanarayana S. Efficiency of a novel calcium/potassium
salt of (-)-hydroxycitric acid in weight control Int J Clin Pharmacol
Res 2005;25(3:133-44.). It was also noted that serotonin levels
were significantly increased by HCA. Serotonin is a neurotransmitter
which, when low, signals hunger and particularly carbohydrate cravings.
[0055] In an embodiment of the present invention, which is set
forth in greater detail in Example 1 below, The diet supplement
may include the Calcium and Potassium double salt of Garcinia Cambogia
Extract standardized to about 60% Hydroxycitric Acid. A serving
of the diet supplement may include from about 100 mg to about 5
g of the Calcium and Potassium double salt of Garcinia Cambogia
Extract standardized to about 60% Hydroxycitric Acid. The preferred
dosage, in a serving of the diet supplement, comprises about 1.555
g of the Calcium and Potassium double salt of Garcinia Cambogia
Extract standardized to about 60% Hydroxycitric Acid.
[0056] Rhodiola Rosea
[0057] Rhodiola Rosea is also known as `Golden root`, `Arctic root`
and Crenulin. Typically, it is considered to be an `adaptogen` due
to the observed ability of Rhodiola to confer increased resistance
to multiple stresses, both mental and physical (Kelly G S, Rhodiola
rosea: a possible plant adaptogen Altern Med Rev. 2001 Jan:6(3):293-302.).
The mechanism of action for Rhodiola Rosea appears to be primarily
its ability to increase the levels of monamine neurotransmitters
such as serotonin, dopamine and norepinephrine (Stancheva S L, Mosharrof
A, Effect of the extract of Rhodiola rosea L, on the content of
the brain biogenic monamines, Med Physiol 1987:40:85-87.). In vivo
experiments in rats show that Rhodiola possesses both cardioprotective
(Lishmanov IuB, Maslova L V, Maslov L N, Dan'shina E N, [The anti-arrhythmia
effect of Rhodiola rosea and its possible mechanism] Biull Eksp
Biol Med. 1993 Aug:116(8):175-6.) and anticancer properties (Udinlsev
S N, Shakhov V P. The role of humoral factors of regenerating liver
in the development of experimental tumors and the effect of Rhodiola
rosea extract on this process. Neoplasma 1991: 38(3):323-331.).
Using in vitro studies on human cells, it was demonstrated that
Rhodiola extract has marked protective and antioxidant activity
(De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchianni L, Dacha
M, in vitro protective effect of Rhodiola rosea extract against
hypochlorous acid-induced oxidative damage in human erythrocytes
Biofactors, 2004:20(3):147-59.).
[0058] In human clinical trials, Rhodiola has been shown to improve
mental performance (Darbinyan V, Kleyan A, Panossian A, Gabriellian
E, Wikman G, Wagner H, Rhodiola rosea in stress induced fatigue--a
double blind cross-over study of a standardized extract SHR-5 with
a repeated low-dose regimen on the mental performance of healthy
physicians during night duty. Phytomedicine, 2000 Oct:7(5):365-71.;
Shevtsov V A, Zholus B I, Shervarly V I, Vol'skij V B, Korovin Y
P, Khristich M P, Roslyakova N A, Wikman G. A randomized trial of
two different doses of a SHR-5 Rhodiola rosea extract versus placebo
and control of capacity for mental work. Phytomedicine, 2003 Mar:10(2-3):95(105.)
and reduce stress-induce fatigue without side-effects (Spasov A
A, Wikman G K, Mandrikov V B, Mironova I A, Neumoin W. A double-blind,
placebo-controlled pilot study of the stimulating and adaptogenic
effect of Rhodiola rosea SHR-5 extract on the fatigue of students
caused by stress during an examination period with a repeated low-dose
regimen. Phytomedicine, 2000 Arr;7(2):85-9.). Furthermore, Rhodiola
can also improve endurance exercise performance (De Beck K, Eijnde
B O, Ramaekers M, Hespel P, Acute Rhodiola rosea intake can improve
endurance exercise performance, Int J Sport Nutr Exerc Metab, 2004
Jun;14(3):298-307.).
[0059] In an embodiment of the present invention, which is set
forth in greater detail in Example 1, the diet supplement may include
Rhodiola Rosea Leaf Extract. A serving of the diet supplement may
include from about 1 mg to about 1 g of Rhodiola Rosea Leaf Extract.
The preferred dosage, in a serving of said diet supplement, comprises
about 124 mg of Rhodiola Rosea Leaf Extract.
[0060] The diet supplement according to this invention provides
a method for causing rapid weight loss, controlling appetite, managing
stress, supporting relaxation, and supporting mental well-being.
Advantageously, consumption of the diet supplement is combined with
a reduced calorie diet and a program of regular exercise.
[0061] According to various embodiments of the present invention,
the diet supplement may be consumed in any form. For instance, the
dosage form of the diet supplement may be provided as, e.g., a powder
beverage mix, a liquid beverage, a ready-to-eat bar or drink product,
a capsule, a tablet, a caplet, or as a dietary gel. The most preferred
dosage form is a caplet.
[0062] Preferably, the diet supplement is consumed by an individual
in accordance with the following method: As a diet supplement, 2
caplets may be taken with an 8 oz. glass of water three times daily.
Preferably each serving, comprised of 2 caplets may be consumed
approximately 30 to 60 minutes before each meal, e.g., breakfast,
lunch and dinner. In this manner, the diet supplement may cause
rapid weight loss, control appetite, manage stress, support relaxation,
combat fatigue and support mental well-being for an extended period
of time, e.g., all day.
[0063] Furthermore, the dosage form of the diet supplement may
be provided in accordance with customary processing techniques for
herbal and dietary supplements in any of the forms mentioned above.
Furthermore, the diet supplement set forth in the example embodiments
herein may contain any appropriate number and type of excipients,
as is well known in the art.
[0064] In addition, the present invention relates to a method of
manufacturing a diet supplement for causing rapid weight loss, controlling
appetite, and managing stress, supporting relaxation, combating
fatigue and supporting mental well-being. For example, the method
of manufacturing a diet supplement may include the step of mixing
one or more of the Calcium and Potassium double salt of Garcinia
Cambogia Extract, supplying 60% Hydroxycitric Acid, Gymnema Sylvestre
Leaf Extract, Rhodiola Rosea Root Extract, Theanine (gamma-glutamylethylamide),
Astaxanthin, Chromium Polynicotinate, Hoodia Gordonii (e.g., an
extract that does not contain any extract from the root of the plant),
N-olyl-phosphatidyl ethanolamine (NOPE)/EGCG blend, Vinpocetine,
Russian Tarragon Extract (Artemisia dracunculus L. PLANT), N-acetyl
tyrosine, Withania Somnifera Root Extract, Microcrystalline Cellulose,
Dicalcium Phosphate Dihydrate, Stearic Acid, Titanium Dioxide, Water,
Propylene Glycol, Sodium Carboxymethylcellulose, Maltodextrin, Dextrose
Monohydrate, Soy Lecithin, Polysorbate 80, Croscarmellose Sodium,
Magnesium Stearate, Silicon Dioxide, Sucralose, and Ascorbic Acid.
The method of manufacturing the diet supplement may also include
the step of checking for uniformity/homogeneity. In addition, the
method of manufacturing the diet supplement may include the step
of aliquoting the mixture into a serving, e.g., for compression
into a caplet.
[0065] Although the following example illustrates the practice
of the present invention in one of its embodiments, the example
should not be construed as limiting the scope of the invention.
Other embodiments will be apparent to one skilled in the art from
consideration of the specification of the following example.
EXAMPLES
Example 1
[0066] A diet supplement for promoting rapid weight loss, controlling
appetite, managing stress, supporting relaxation, combating fatigue
and supporting mental well-being is provided, the diet supplement
comprising the Calcium and Potassium double salt of Garcinia Cambogia
Extract standardized to about 60% Hydroxycitric Acid (1.55500 g),
Gymnema Sylvestre Leaf Extract (0.133000 g) standardized to 25%
Gymnemic Acids, Rhodiola Rosea Extract (0.124000 G) standardized
to 3% Rosavins. Theanine (0.052000 g). Astaxanthin Algae Extract
(0.00500 g), Chromium-Polynicotinate (0.000133 g), Hoodii Gordonii
(0.020000 g) plant without the roots. N-olyl-phosphatidyl ethanolamine
(NOPE)/EGCG blend (0.00100 g) standardized to 23% NOPE, 20% Polyphenols,
14% EGCG, Vinpocetine (0.00100 g). Russian Tarragon Extract (0.00100
g), N-acetyl tyrosine (0.00100 g), and Withania Somnifera Root Extract
(0.00100 g) standardized to 1.5% Withanolides.
[0067] Directions: As a diet supplement, 2 caplets are administered
with an 8 oz. glass of water threee times daily. Preferably, each
two caplet serving may be consumed approximately 30 to 60 minutes
before each meal, e.g., breakfast, lunch and dinner.
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